The UK and other countries affected by people smuggling must not allow the "vile trade" to pit them against one another, the prime minister will tell a summit aimed at cracking down on illegal migration.
Sir Keir Starmer will call on 40 countries gathering in London this week to join his plans to launch a counter terror-style crackdown on people-smuggling gangs.
Countries including Albania, Vietnam and Iraq - from where migrants have travelled the UK - will join the talks, which are the first of their kind, alongside representatives from France, the US and China.
Ministers and enforcement staff will discuss international co-operation on illegal migration, as well as supply routes, criminal finances and online adverts for people smuggling during the meeting.
Officials from social media companies Meta, X and TikTok will also join discussions on how to crack down on the online promotion of irregular migration.
The PM will announce £33m of funding to set up an international arm of the Crown Prosecution Service (CPS), which will target criminal gangs facilitating small boat crossings from abroad, The Times reported. The approach, paying foreign prosecutors to hunt down people smugglers around the world, mirrors the approach he used to combat Islamist terrorism as leader of the CPS.
The summit comes as the PM faces mounting pressure over small boats, with a record 6,642 migrants having crossed the Channel in 119 boats this year, a 43 per cent jump from this time last year.
Sir Keir is expected to call for unity among the nations involved when he addresses the summit on Monday afternoon.
"This vile trade exploits the cracks between our institutions, pits nations against one another and profits from our inability at the political level to come together," he will say.
The prime minister will point to his time working across borders to foil terrorists when he was director of public prosecutions.
He will add: "I believe we should treat organised immigration crime in the same way.
"I simply do not believe organised immigration crime cannot be tackled. We've got to combine our resources, share intelligence and tactics, and tackle the problem upstream at every step of the people-smuggling routes."
The summit will deliver "concrete outcomes" for nations in Europe, Asia, Middle East, Africa, and North America, according to the Home Office.
Developments aimed at tackling illegal migration ahead of the gathering include:
Speaking ahead of the summit, the Home Secretary said law enforcement needed to "work together across borders" to bring down people smuggling gangs.
She added: "Only a co-ordinated international response across the whole irregular migration route can effectively dismantle these networks.
"The Organised Immigration Crime Summit is the first of its kind and will reinforce the UK's position as a leader by securing international commitments to disrupt Organised Immigration Crime at every stage of the business model.
"The summit demonstrates mine and the Prime Minister's absolute dedication to disrupting the callous organised criminal gangs, strengthening our borders and ultimately save countless lives."
On Sunday, senior Tory shadow minister Alex Burghart said Labour should never have scrapped the Rwanda deportation plan.
"It was ready to go, and Labour came in, they won a majority, and they scrapped it. There is now no deterrent programme," he said.
