Jude Bellingham is set to be rested with Jordan Henderson promoted to England’s starting XI against Wales.
The 19-year-old will be left out after Three Lions sports scientists noted his huge physical input in the first two World Cup Group B matches.
Henderson's positive cameo in the 0-0 draw with the United States sees him promoted in Bellingham’s place.
Gareth Southgate isn't expected to ring a whole host of changes on Tuesday night as he balances resting certain players with keeping rhythm in his team.
Ben White is out ill but James Maddison has returned from a minor knee injury that kept him out of the first two games at this tournament.
Harry Kane avoided injury after a heavy challenge in the 6-2 win over Iran and has been given the all-clear by a scan.
Southgate denied that his captain particularly needs a rest with England requiring a point against Wales to guarantee qualification for the last-16.
"With Harry, we're obviously going to pick a team we can win the game with. That's our priority always,” he said.
"He's fine in terms of the knock he had. We keep saying it’s his foot, and everyone keeps saying it's his ankle. It's his foot.
"There's only Ben White missing with illness. We have everyone available to select from. It makes decisions difficult of course but you want a fully-fit squad. That's where we're at."
