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Joe Manniello

Joe Manniello's Week 6 NFL picks

This is the first week with four teams on the bye. I wouldn't have minded if a few more were, as this week's slate presents some nearly impossible games to predict (what, you think you know what's going to happen between Tennessee and Denver?)

There are a number of small spreads, so expect some close finishes. Underdogs went 7-7-1 against the spread last week and are 46-31-1 for the year. Road teams went 8-6 straight up to improve to 43-34 (not including London games). Even more impressive, they're 48-27-2 ATS, the second-best mark all time through five weeks, according to Odds Shark.

My most confident picks of the week ATS are the 49ers, Seahawks and Saints. Stay away from the aforementioned Titans-Broncos game as well as Steelers-Chargers.

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