All bets are off in Week 1, except of course in the literal sense, as fans can't resist the urge to wager on their favorite sport after a seven-month absence.
This is the most unpredictable week of any NFL season, when most upsets shouldn't shock you because, let's face it, things change in a hurry in this league. Be on the lookout for teams with new coaches or new quarterbacks (or both), and teams that could be facing a letdown or a revival.
My six most confident picks against the spread (ATS) are the Colts, Browns, Cardinals, Jaguars, Eagles and Bills. Two tricky games to stay away from: 49ers-Bucs and Falcons-Vikings.
