After France's defeat to Ireland on Saturday evening, England will know that wins in their remaining games could well mean the title head to Twickenham with France to play in Paris on the final day, also known as Super Saturday.
Despite defeat to Scotland, England will be confident of doing just that after beating the world champions South Africa in the autumn but they will need a big win against Italy on Sunday afternoon to kick things off.
Eddie Jones has opted for an exciting line-up with Harry Randall being given his first Six Nations start at scrum-half while Jack Nowell is picked on the wing for his first England start since the 2019 World Cup.
Alex Dombrandt starts in place of Sam Simmonds at Number 8 while Jamie George is called in for Luke Cowan-Dickie as Jones shuffles his pack.
The other changes are Charlie Ewels in for the injured Lewis Ludlam while Will Stuart is in for Bristol's Kyle Sinckler in a move that suggests Jones may be resting some players ahead of the rest of the tournament.
Italy, meanwhile, have dropped their try-scoring star Tommaso Menoncello, 19, from their squad entirely with 21-year-old Bordeaux winger in to start - Pietro Ceccarelli makes his first Six Nations start with Braam Steyn also starting in the place of Sebastian Negri.
With Italy looking strong it could be a stern test for England but one they should come away from with a bonus point if there is any chance of winning the title, here are all the key details ahead of Sunday's match.
What time is kick-off?
The match takes place on Sunday 13 February at the Stadio Olympico, kicking off at 3:00pm.
Where can I watch the match?
You can watch the match live on ITV One, or it can be streamed via ITV Hub.
What are the confirmed lineups?
Italy XV: Padovani, Mori, Brex, Zanon, Ioane, Garbisi, Varney, Fischetti, Lucchesi, Ceccarelli, Cannone, Ruzza, Steyn, Lamaro, Halafihi.
Replacements: Faiva, Traore, Pasquali, Sisi, Negri, Pettinelli, Fusco, Marin.
England XV: Steward, Malins, Marchant, Slade, Nowell, Smith, Randall, Genge, George, Stuart, Ewels, Isiekwe, Itoje, Curry, Dombrandt.
Replacements: Cowan-Dickie, Marler, Sinckler, Chessum, Simmonds, Youngs, Ford, Daly.
What is the head to head record?
When it comes to the head to head record, Italy and England have contested a total of 28 Test matches since their first meeting in 1991, with England maintaining a 100% record.
