Vera Pauw's Republic of Ireland side head to Hampden Park on Tuesday evening knowing that a win is a must if they are to qualify for next year's World Cup.
Ireland are the third-ranked team in the Second Round of the Play-Offs, behind both Switzerland and Iceland, who face Wales and Portugal respectively in their Play-Off contests.
The two best ranked winners – based on qualification record – will punch their tickets to the World Cup.
READ MORE: Follow our LIVE BLOG of Ireland v Scotland right here
The third winner qualifies for the FIFA Women’s Inter-Confederation Play-Off in February 2023.
This will be the 22nd encounter between the two sides at women's senior level, but the stakes have never been higher as Pauw's Irish side look to qualify for next year's World Cup in Australia and New Zealand.
And the Irish manager is ready for the challenge of Scotland.
She said: "We have full respect for Scotland, who are a very direct team with a lot of excellent players and they fully deserved to beat Austria in the first round of this play-off series.
"We have watched them closely and know that we will be facing a very difficult opponent who will also have a home crowd behind them.
"We believe in ourselves and trust in each other - players and staff - but we know that we have to be at our very best if we are to win this game. Making it to the World Cup has always been the dream."
Here is all you need to know ahead of the game.
Where and when is it?
This game takes place at Hampden Park on Tuesday, October 11.
What time is kick off?
Kick off is at 8pm.
What channel is it on?
The game will be shown live on RTE Two television, where coverage starts at 7.45pm.
Team news
Ireland are armed with the services of all of the 27 players who have travelled to Glasgow as part of the matchday squad. Savannah McCarthy (knee), Ruesha Littlejohn (foot), Megan Connolly (ribs), Ellen Molloy (knee), Jess Ziu (knee), Leanne Kiernan (ankle) and Aoife Colvill (knee) are all unavailable and were not selected in the initial squad.
Betting odds
Ireland - 10'3
Scotland - 13/20
Draw - 5/2
