Glasgow Warriors will host the first leg of the 1872 Cup against Edinburgh at Hampden in an "unprecedented move for rugby".
The Scotstoun club will play the opening leg of the competition at Hampden on Sunday, December 22. Kick-off will be at 3pm.
Tickets for the match will go on general sale on Friday, October 25 at 10am.
Warriors managing director Al Kellock commented: “This is a massive moment in the history of not just our club, but rugby within our city and our Glasgow Warriors community.
“To be able to take one of our biggest games of the season to one of Scotland’s national stadia is a reflection of the journey that we have been on as a club, as we continue to grow the game in our city, the west of Scotland and Caledonia regions.
“It’s a journey that has seen the Warrior Nation follow us through thick and thin; from the club grounds across Scotland that shape our Warriors, to the high veldt in Pretoria where we became URC champions. To be able to take this fixture to Hampden is a reflection of the support upon which this club is built, and we know that our supporters will make Hampden an atmosphere unlike any other.
“We’re excited by the opportunity this fixture presents, not only on the field but off it as well – we also hope to welcome a new audience that may otherwise not attend a Glasgow Warriors match, especially in the run-up to the festive holidays.
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“I’d like to thank everyone involved in making this fixture happen, from our friends at the Scottish FA, Scottish Rugby, United Rugby Championship and Premier Sports, to the efforts of everyone involved at Scotstoun.
“Our ask to the Warrior Nation is to now make this as big an occasion as we possibly can – I firmly believe that we have earned the opportunity through our performances over the last season, to show our club, our values and our players to a new audience on one of Scotland’s biggest stages. We know that Glasgow is not just a football city – let’s show that to the world.”
Captain Kyle Steyn - speaking to the club website - added: “It’s such an exciting opportunity – derby matches are already the type of fixture that you want to be involved in as a player, so to have the chance to run out at an iconic Glasgow venue is extremely special.
“Having our own ‘big game’ concept is an outstanding reflection of the support that this club has year in, year out – they get behind us wherever we are, and they give us that extra edge time and again.
“We know that 1872 Cup atmospheres are always electric, and I can’t wait to see and hear the buzz that the Warrior Nation will create at Hampden.”