GWS co-captain Toby Greene won't play again this AFL season after having an operation on Tuesday.
The star Giant fractured his thumb in the warm-up before his side's 27-point win against Essendon on Saturday, with specialist advice on Monday confirming he would need to undergo surgery.
It ends another impressive campaign for Greene, who slotted 37 goals in 15 games despite his side's underwhelming form.
The club, who sit 16th on the ladder with a 6-14 record, also says Tim Taranto won't play against the Western Bulldogs on Saturday as he goes through concussion protocols.
Taranto suffered a delayed concussion from the Giants' previous clash against Sydney.
Forward James Peatling was concussed in the win over the Bombers and won't play this weekend either.