A 49-year-old dad died of cancer after he was misdiagnosed at hospital, an inquest has heard.
David Hulme was told he was suffering from sarcoidosis, a rare condition that causes small patches of red and swollen tissue, in 2014. However, years later in 2021 he was diagnosed with lymphoma - a cancer of the lymph system - and passed away just one month later.
Senior coroner heard evidence of understaffing at Derriford Hospital from medical workers and said he will be writing to the local NHS trust to express his concerns, Wales Online reports.
A pathologist told the inquest that she had noticed signs of "granulomatous inflammation" in Mr Hulmes tissue in the summer of 2020, a symptom in keeping with the previous diagnosis of sarcoidosis. It can be a sign of cell injury caused by a variety of conditions but she said that due to the high inflammation it was extremely hard to examine the samples and by using the clinical history of the patient she felt comfortable that she could rule out cancer.
She said: "I did not feel in my experience that this was a malignant condition. At the time I felt it was benign." In fact Mr Hulme had "high grade B cell lymphoma" in his right lung. He had previously complained of breathing difficulties and an ongoing cough.
The pathologist said the placement and exact condition was extremely rare. "The diagnosis is very, very, extremely difficult and unprecedented in my career. I have never come across it or even heard of it," she said.
She told the hearing that in her job she is "reliant on clinical context" and due to the previous diagnosis of sarcoidosis she felt that was the most likely cause of Mr Hulme's condition. A reassessment and a second opinion of the tissue sample was only gained in early 2021 when the pathologist was informed of a "change in clinical status" to Mr Hulme.
A consultant pathologist at Royal Brompton Hospital in London informed staff at Derriford Hospital that he was "worried that it could be lymphoma". Although Mr Hulme did receive treatment for lymphoma prior to his death it was unable to prolong his life longer than a month.
Ms Carmell, a legal representative of the Hulme family, pressed the pathologist on why she had not sought a second opinion at the time of the first examination. She said: "I wish that I had sought a second opinion. I apologise to the family for that."
The pathologist stated the only work colleague at Derriford Hospital who would have been able to look at the sample was "overworked with work up to his ceiling" and had recently swapped to working part-time hours. The pathologist also acknowledged that in her occupation doctors are not "always good at showing uncertainty" and instead are taught to "come down on one side".
A senior colleague at Derriford Hospital explained the hospital had completed a "root cause analysis" of the events which led to Mr Hulme's death. He stated that the combination of confirmation bias and the complex nature of the case led to individual error in diagnosing Mr Hulme.
The analysis conducted also uncovered a series of problems, contributory factors and recommendations going forward to ensure a similar incident would not happen again. Included within the findings was evidence of increased staff workload, a lack of consultants and a lack of formal training.
The senior colleague stated that a new operating system had been developed which would help pathologists seek a second opinion. A new forum has also been set up which will see pathologists meet quarterly to discuss difficult cases, specifically the problems and lessons they had learnt from working with the patient.
The pathologist present at the inquest added that her fellow colleagues believed she "acted with integrity at the time". Recording a narrative conclusion, Mr Arrow said Mr Hulme had died as a result of "high grade B cell lymphoma", which was a "naturally occurring condition".
Mr Arrow said that Mr Hulme died from cancer. He informed those giving evidence that he would be writing to the CEO of Derriford Hospital with the advice that staffing levels should be investigated.
Before ending the inquest and addressing the Hulme family, Mr Arrow said: "I would like the opportunity to pass on my condolences to the family. I am very sorry to have heard of your loss."
Mr Hulme was a dad to Kieran and Joe, aged 21 and 15 respectively and had previously served in the Royal Navy. Mr Hulme's wife described her partner of 19 years as a "fantastic husband".
She said: "He was such a fantastic husband and dad to our boys, and to this day I still feel myself going to speak to him and then realising he’s not here anymore. We all miss him every single day.
"Since he died, I feel like time has stood still for me. He was my soulmate and I really can’t imagine the rest of my life without him.
"I know nothing will ever bring him back, and I know reliving it all at the inquest will be tough but I hope that it will at least provide us with the answers we need."
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