Russell led for the majority of the race, while his team-mate Lewis Hamilton was hit by his old Red Bull nemesis Max Verstappen following a restart, which forced Verstappen to pit for a new nose.
Hamilton dropped to eighth but recovered back to second, finishing ahead of both Ferraris. Verstappen recovered to finish sixth.
2022 Brazilian Grand Prix results
| Cla | Nº | Driver | Car / Engine | Laps | Time | Delay/Retirement |
| 1 | 63 | George Russell | Mercedes | 71 | - | |
| 2 | 44 | Lewis Hamilton | Mercedes | 71 | 1.529 | |
| 3 | 55 | Carlos Sainz Jr. | Ferrari | 71 | 4.051 | |
| 4 | 16 | Charles Leclerc | Ferrari | 71 | 8.441 | |
| 5 | 14 | Fernando Alonso | Alpine/Renault | 71 | 9.561 | |
| 6 | 1 | Max Verstappen | Red Bull | 71 | 10.056 | |
| 7 | 11 | Sergio Pérez | Red Bull | 71 | 14.080 | |
| 8 | 31 | Esteban Ocon | Alpine/Renault | 71 | 18.690 | |
| 9 | 77 | Valtteri Bottas | Alfa Romeo/Ferrari | 71 | 22.552 | |
| 10 | 18 | Lance Stroll | Aston Martin/Mercedes | 71 | 23.552 | |
| 11 | 5 | Sebastian Vettel | Aston Martin/Mercedes | 71 | 26.183 | |
| 12 | 10 | Pierre Gasly | AlphaTauri/Red Bull | 71 | 26.867 | |
| 13 | 24 | Zhou Guanyu | Alfa Romeo/Ferrari | 71 | 29.325 | |
| 14 | 47 | Mick Schumacher | Haas/Ferrari | 71 | 29.899 | |
| 15 | 23 | Alexander Albon | Williams/Mercedes | 71 | 36.016 | |
| 16 | 6 | Nicholas Latifi | Williams/Mercedes | 71 | 37.038 | |
| 17 | 22 | Yuki Tsunoda | AlphaTauri/Red Bull | 70 | - | 1 lap |
| 4 | Lando Norris | McLaren/Mercedes | 50 | - | Retirement | |
| 20 | Kevin Magnussen | Haas/Ferrari | 0 | - | Collision | |
| 3 | Daniel Ricciardo | McLaren/Mercedes | 0 | - | Collision | |
How the Brazilian Grand Prix unfolded
Russell held his pole advantage on the run to Turn 1, leading Hamilton and the Red Bulls of Verstappen and Sergio Perez. McLaren’s Lando Norris attacked Perez down the inside at Turn 1 but soon had both Ferraris on his tail. Moments later, Daniel Ricciardo’s McLaren tapped Friday’s polesitter Kevin Magnussen into a spin at Turn 8 and collected Ricciardo, who clattered into the barrier.
The race went green on lap seven, with Russell heading Hamilton, Verstappen, Perez and Norris. Verstappen lunged around the outside of Hamilton at the Senna-S and they collided approaching the apex of Turn 2, causing Verstappen to pit for a new front wing as Hamilton dropped to eighth.
Norris then punted Ferrari’s Charles Leclerc off the track at Ferradura, sending him spinning into the wall and into the pits for a new nose. Verstappen and Leclerc dropped to 17th and 18th respectively, with Verstappen and Norris both receiving five-second penalties.
Russell extended his lead to 1.5s by lap 10, as Ferrari’s Carlos Sainz passed Norris for third at Turn 1. Aston Martin’s Sebastian Vettel was now up to fifth, ahead of the recovering Hamilton – who passed Mick Schumacher (Haas) and Pierre Gasly (AlphaTauri) in succession.
Hamilton passed Vettel at Turn 1 on lap 14 for fifth, and DRS-ed past Norris for fourth a lap later. Vettel moved past Norris on lap 17 to claim fifth, while Sainz was forced to pit early due to a visor tear-off getting stuck in his right-rear brake duct, which put Hamilton back into the podium positions.
Russell was almost four seconds clear when Perez stopped on lap 24, and he rejoined mired in traffic. Russell pitted a lap later, and despite a slower stop, rejoined 3.6s clear and with Vettel between them until he pitted on lap 27.
Hamilton led at this point, and ran long until pitting on lap 30, rejoining in fourth behind Russell, whose lead at half distance was up to almost 6s over Perez.
Hamilton quickly caught Perez, as Sainz pitted early to try and undercut the Red Bull. Hamilton passed Perez on track into Turn 1 on lap 45, but was 10s behind Russell.
Perez pitted on lap 48, rejoining 11s behind Sainz, who was elevated to third. Hamilton stopped a lap later, rejoining on softs behind Sainz but ahead of Perez.
Russell pitted from the lead with 21 laps remaining, taking softs like Hamilton, and rejoined just a second ahead of Sainz.
Norris lost power and ground to a halt on lap 52, causing a virtual safety car. Sainz opted to pit again, dropping him to fourth but now running on softs, but as marshals couldn’t move Norris’s car and it was upgraded to a full safety car.
At the restart with 12 laps remaining, Russell led Hamilton, Perez and Sainz. Leclerc grabbed fifth from Valtteri Bottas (Alfa Romeo) as Sainz attacked Perez for third – almost touching at the exit of the Senna-S.
Russell pulled out of Hamilton’s DRS range and stroked it home for his first F1 win, as Sainz DRS-ed past Perez into Turn 4 for third, and Leclerc did likewise into Turn 1 a lap later.
Fernando Alonso surged up to fifth in the closing stages for Alpine, while Verstappen passed two cars in one go to grab seventh and then picked off Perez for sixth, where he finished despite being asked to give Perez the position back.
