Michael Keane starts for Everton as he replaces Yerry Mina in the starting line-up for Watford.
Mina was forced off after just 16 minutes at Leicester City on Sunday and Frank Lampard has since confirmed the defender is unlikely to be available again before the Blues face Arsenal on the final day of the season.
Everton will be hoping they have confirmed their Premier League status by then - and they could take a huge stride towards that goal with three points at Vicarage Road tonight.
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Keane, who replaced Mina at the King Power Stadium, is the only change to Everton's starting line-up. That means coaching staff have kept faith in the fitness of Fabian Delph, whose recent return from injury has led to questions about whether he can play games in quick succession.
The big question from the line-ups is whether Alex Iwobi will operate as a right-wing back when the opponents have possession - as he did in the wins over Leicester and Chelsea - or whether he will return top his favoured role as an attacking centre midfielder.
Tom Davies makes his second appearance on the bench as he continues his recovery from a long-term injury.
Team: Pickford, Coleman, Mykolenko, Holgate, Keane, Delph, Doucoure, Iwobi, Richarlison, Gordon, Gray
Subs: Begovic, Kenny, Allan, Calvert-Lewin, Gomes, Davies, Branthwaite, Rondon, Alli.
