Jarrad Branthwaite starts at centre-back for Everton against Brentford as Michael Keane misses out from the squad entirely.
Frank Lampard confirmed before kick-off Keane is absent through illness.
Jordan Pickford continues in goal along with full-backs Seamus Coleman and Vitaliy Mykolenko but Branthwaite comes in to partner Mason Holgate.
Andre Gomes returns to the starting line-up for the first time since February as Fabian Delph is ruled out. Abdoulaye Doucoure keeps his place in midfield alongside him.
Richarlison, Alex Iwobi and Anthony Gordon also continue but Demarai Gray drops to the bench as Dominic Calvert-Lewin leads the line from the start for the first time since the win over Manchester United last month.
Everton: Pickford; Coleman, Holgate, Branthwaite, Mykolenko; Doucoure, Gomes; Richarlison, Iwobi, Gordon, Calvert-Lewin
Substitutes: Begovic, Kenny, Allan, Gray, Davies, Rondon, Dele, Price, Welch