Bristol Bears duo Harry Randall and Kyle Sinckler have been named in England's initial 36-man training squad in preparation for the Six Nations.
England kick-off their campaign against Scotland at Murray on Saturday, February 5 and head coach Eddie Jones will run the rule over his group at a five-day training camp in Brighton next week.
Randall, who was exceptional for the Bears in their victory over Stade Francais in the Champions Cup, and has two caps to his name after earning his first call-up 12 months ago is one of three scrum-halves selected alongside Leicester's Ben Youngs and Raffi Quirke of Sale.
The more experienced Sinckler, meanwhile, is in line to win his 50th cap for his country should he play in at least three matches in the competitions.
The squad also features incoming Bears signing Ellis Genge and Max Malins, who enjoyed an impressive loan spell at Ashton Gate last season.
"Selecting this squad has been a difficult task, we've got plenty of good young players coming through and some of our more experienced are rediscovering their best form," Eddie Jones said.
"We think this 36 for the first training week reflects a good balance of that experience and up-and-coming talent. The Six Nations is going to be the most competitive we've ever seen. All the countries performed well in the autumn, so we need to be at our best and improve with every game."
Owen Farrell has been retained as captain but George Ford continues to miss out despite his outstanding form at the heart of Leicester's revival with Farrell, Marcus Smith and uncapped Bath prospect Orlando Bailey included as fly-halves.
There is no place for versatile back Elliot Daly despite his recovery from the stress fracture that forced him to sit out a successful autumn, and his Saracens colleagues Mako and Billy Vunipola also remain in international exile.
A fifth ever-present from the 2019 World Cup squad, and up until now a key member of Eddie Jones' back row, has been frozen out in flanker Sam Underhill.
The uncapped Bailey, Alfie Barbeary, Ollie Chessum, Tommy Freeman, Ollie Hassell-Collins and Luke Northmore continue Jones' overhaul of his England squad as he builds for France 2023.
Despite the rebuilding process that began an autumn that produced victories over Tonga, Australia and South Africa, Farrell has seen off stiff competition from Ford to continue as an option at fly-half and inside centre.
And his inclusion comes despite his last outing coming against the Wallabies in November when he sustained an ankle injury that required surgery. He is due to make his comeback against London Irish on Sunday.
Smith is favourite to retain the number 10 jersey, leaving 12 as Farrell's likely slot in the back line.
Meanwhile, Exeter wing Jack Nowell makes his first appearance in an England squad since the World Cup, having recovered from a succession of injuries.
Of the newcomers, Barbeary is the most likely to be involved in the Six Nations as the 21-year-old back row, who can also play hooker, continues to impress for Wasps.
England's Six Nations squad
Forwards: Alfie Barbeary (Wasps), Jamie Blamire (Newcastle Falcons), Ollie Chessum, (Leicester Tigers), Luke Cowan-Dickie (Exeter Chiefs), Tom Curry (Sale Sharks), Alex Dombrandt (Harlequins), Charlie Ewels (Bath Rugby), Ellis Genge (Leicester Tigers), Jamie George (Saracens), Joe Heyes (Leicester Tigers), Jonny Hill (Exeter Chiefs), Maro Itoje (Saracens), Courtney Lawes (Northampton Saints), Lewis Ludlam (Northampton Saints), Joe Marler (Harlequins), Bevan Rodd (Sale Sharks), Sam Simmonds (Exeter Chiefs), Kyle Sinckler (Bristol Bears), Will Stuart (Bath Rugby)
Backs: Mark Atkinson (Gloucester Rugby), Orlando Bailey (Bath Rugby), Owen Farrell (Saracens), Tommy Freeman (Northampton Saints), George Furbank (Northampton Saints), Ollie Hassell-Collins (London Irish), Max Malins (Saracens), Joe Marchant (Harlequins), Jonny May (Gloucester Rugby), Luke Northmore (Harlequins), Jack Nowell (Exeter Chiefs), Raffi Quirke (Sale Sharks), Harry Randall (Bristol Bears), Henry Slade (Exeter Chiefs), Marcus Smith (Harlequins), Freddie Steward (Leicester Tigers), Ben Youngs (Leicester Tigers)
