Eddie Jones has already had to contend with a few major setbacks since announcing his Six Nations squad, and the England coach is prepared for any vaccine -related changes to come during the tournament.
Current Covid-19 restrictions in Great Britain and Ireland mean unvaccinated players still have a chance to feature, but that won't be the case for games in France and Italy.
The vaccine pass systems in those countries mean even professional athletes aren't exempt from regulations, demanding anyone entering public venues like stadia must be double-jabbed.
There were concerns players like Henry Slade would be barred from such fixtures having previously spoken out against the Covid-19 vaccine last year.
However, Slade dismissed any doubts regarding his vaccine status after he was cleared to play in Exeter 's 37-26 Champions Cup defeat away to Montpellier earlier in January.
It doesn't appear as though that's the end of the story in regards to potential absences due to the vaccine, however, as head coach Jones said England will replace staff if needed.
"I'm not a doctor, I don't ask Tom, 'show me your vaccination status' - that's not part of the selection criteria," he said speaking alongside Tom Curry during the virtual Six Nations launch, as quoted by Sky News .
"When we work out what you need to have to get into France and if there are players ineligible or staff ineligible, then we'll find replacements."
England open their Six Nations campaign away to Scotland at Murrayfield on February 5 before visiting Rome to face Italy the following weekend (February 13).
They'll then host Wales (February 26) and Ireland (March 12) at Twickenham before travelling to Paris to take on France (March 19) in the final round, when Jones will want as many of his players available as possible.
Where do you think England will place at the 2022 Six Nations? Let us know in the comments section.
"I don't see it as a big deal, we're certainly not treating it as a big deal," he continued. "Our players who want to get vaccinated, are vaccinated, the players who don't want to get vaccinated, aren't vaccinated.
"There's no compulsion of the RFU or the England team management for the players to do anything that they don't want to do.
"It's their personal choice and we're looking forward to going to France, that's going to be a great game and everyone who is vaccinated will certainly be enjoying that experience."
Red Rose captain Owen Farrell was ruled out of the tournament on Wednesday after undergoing ankle surgery following an injury while training with Saracens last week.
Winger Jonny May may also be ruled out of the entire competition following knee surgery, while Courtney Lawes is a doubt for the Calcutta Cup clash with Scotland due to a head injury.
To add further to Jones' selection headaches, Harlequins prop Joe Marler is in a race to be available for the trip to Murrayfield after he tested positive for Covid earlier this week.
Meanwhile, Victor Ubogu represented England on 24 occasions between 1992 and 1999, but the former Bath prop now operates a travel and hospitality company that takes large groups of fans to events like the Six Nations.
"In terms of the players it is a very clear-cut rule, if you are not vaccinated you are not going to get into Italy, you are not going to get into France," he told Sky News.
"Fans - you are not going to get into Italy, you are not going to get into France, so you have to get vaccinated if you want to go to those places. If you choose not to be vaccinated then it is a non-starter."
Many would consider it fair that policy extends to pro athletes during a global pandemic, and it's possible Scotland or Ireland may also have unjabbed players who won't be available for trips abroad.
