Italian bosses Cristian Stellini and Roberto De Zerbi were both sent to the stands during a furious row between the coaching staff of Tottenham and Brighton at the Tottenham Hotspur Stadium.
The pair were both dismissed by referee Stuart Attwell for failing to control their respective benches as tensions rose just before the hour mark of the match, which Spurs went on to win 2-1.
With a row erupting, players from both sides ran to try and calm the situation down, although Stellini, Antonio Conte's former assistant manager, stayed out of the situation initially.
De Zerbi had become incensed as Brighton saw two goals disallowed either side of half-time, with the score standing at 1-1 during the time of the melee.
Earlier De Zerbi had confronted Stellini before the match had even kicked off, with the Seagulls boss seemingly taking exception to comments from the Tottenham caretaker manager at Friday's pre-match press conference.
Stellini had suggested that Brighton's successes under De Zerbi were largely the work of previous manager Graham Potter, who left the club for Chelsea in September last year.
Former Sassuolo and Shakhtar Donetsk manager De Zerbi seemingly took exception to those comments from his compatriot, which were widely reported in Italy, and he could be seen angrily gesturing towards Stellini as both sets of players lined up to kick off.
Describing the scene for BBC Radio Five Live, commentator Jonathan Overend said: "Embarrassing scenes on the touchline. It's absolutely ridiculous, they should be ashamed of themselves. the players came over to stop this melee, ridiculous.
"Both managers have been sent off and frankly it's the least they deserve for starting that melee."
Pundit Dion Dublin questioned Stellini's dismissal though, saying: "Cristian Stellini was about five yards away, he didn’t have anything to do with it.
"He wasn’t taking any notice at all."
Tottenham had taken the lead in the game when Son Heung-min became the first Asian player to reach 100 Premier League goals with a strike from distance, before Lewis Dunk equalised for the visitors.
Both Kaoru Mitoma and Danny Welbeck then had goals disallowed for De Zerbi's side, who also thought they should have had been awarded a penalty by Attwell before Harry Kane restored Tottenham's lead with what proved to be the winner.
