Richmond will rest veteran premiership heroes Trent Cotchin and Jack Riewoldt for their clash with the resurgent Western Bulldogs at the MCG.
The Tigers will be without their three-time premiership captain and Riewoldt, the fourth most prolific goal-kicker in the club's storied history.
Cotchin has been listed as "managed" after playing in Richmond's first three games of the season but has been included as an emergency for Saturday's match.
Keeping Cotchin, who turns 33 on Friday, in as an emergency could indicate Richmond are thinking of using the midfielder as their sub.
The former Richmond captain is averaging 19 disposals to start this season, but coach Damien Hardwick has indicated Cotchin would be used more up forward this year.
Riewoldt has kicked three goals across the first three rounds, including two in last week's loss against Collingwood.
As floated earlier in the week, superstar Dustin Martin and recruit Jacob Hopper will return with Maurice Rioli Jnr and Jack Ross making way.
After notching up their first win of the season last week, the Bulldogs' only out is the injured Riley Garcia.
Port Adelaide have swung the axe following their disappointing Showdown defeat to Adelaide, dropping Tom Clurey, Darcy Byrne-Jones, Lachie Jones and Riley Bonner for their trip to Sydney to face the Swans.
Dynamic small forward Orazio Fantasia is out injured for the Power.
North Melbourne will welcome back exciting midfielder Luke Davies-Uniacke and co-captain Jy Simpkin for their Good Friday match against Carlton at Marvel Stadium.
Davies-Uniacke played a pivotal role in the Kangaroos' victories against West Coast and Fremantle but was a late withdrawal for last week's defeat to Hawthorn.
Buoyant Gold Coast will head to Marvel Stadium for their Saturday night clash with unbeaten St Kilda with debutant Bailey Humphrey.
Taken with pick six in last year's draft, Humphrey has impressed in the VFL and is one of two Suns inclusions after their memorable win against reigning premiers Geelong.
Exciting tall Mac Andrew will make his first AFL appearance of the year following a troubled off-season when he was charged with drink-driving.
St Kilda have enjoyed some relief from their rotten injury luck with in-form utility Mason Wood cleared for the match against the Suns.
