The Indianapolis Colts (2-2-1) will host the Jacksonville Jaguars (2-3) at Lucas Oil Stadium for a Week 6 matchup.
Though the Colts got blown out on the road in Week 2 in the first meeting between these two teams, Vegas has Indy slightly favored in this matchup entering the weekend.
Here’s how the experts view this Week 6 matchup:
| Expert | Pick | Score (if applicable) |
| Nate Davis (USA TODAY) | Colts | 23-20 |
| Jarrett Bell (USA TODAY) | Jaguars | 20-19 |
| Vic Tafur (The Athletic) | Jaguars | — |
| Mike Clay (ESPN) | Jaguars | — |
| Dan Graziano (ESPN) | Colts | — |
| Gregg Rosenthal (NFL Network) | Jaguars | 20-17 |
| Bill Bender (Sporting News) | Jaguars | 19-17 |
| Pete Prisco (CBS Sports) | Jaguars | 24-17 |
| Adam Stites (Jaguars Wire) | Jaguars | 24-13 |
| Jess Root (Sportsbook Wire) | Colts | — |
| Cam DaSilva (Sportsbook Wire) | Jaguars | — |
| Bleacher Report | Colts | 26-21 |
Over at Tallysight, 64% of the experts are taking the Jaguars to win this game. Considering the 24-0 blowout in Week 2, it’s not all that surprising.
The Colts have to figure out their issues on the offensive line, and it’s likely another change is on the way for Week 6. With Bernhard Raimann getting another start at left tackle—and likely holding the job for the foreseeable future—we may see Matt Pryor move to right guard and Braden Smith back to right tackle.
If that combination somehow turns things around, the Colts will have a much better chance at winning this game. However, those issues along the offensive line are so deficient, it’s difficult to have confidence the offense will turn it around in the course of one week.
This matchup, though, seems to be shaping up to be a much closer outcome than what transpired in Week 2.
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