NSW Health has appointed Multiplex as principal contractor for the $835 million John Hunter Health and Innovation Precinct.
The project is due for completion in 2026 and will include a seven-storey acute services building, new emergency department and more adult and paediatric critical care spaces.
The plans also include a birthing suite and inpatient maternity unit, neonatal intensive care unit, special care nursery, operating theatres, rooftop helipad and more than 900 new car spaces.
Parliamentary Secretary for the Hunter Taylor Martin said up to 800 workers were expected on site each day.
"Significant progress has already been made on site and the community can now see the scale of the project and the huge amount of work that has been done to prepare for construction of the new seven-storey acute services building in the coming weeks," he said.
Multiplex also built the new Maitland Hospital.
The company will establish a "connection" centre to help employ primarily disadvantaged local job seekers during construction.
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