A woman in China recently died of H3N8, a subtype of bird flu that has only infected three known people to date, the World Health Organization (WHO) reported Tuesday (April 11).
All three human cases of H3N8 have been reported in China. The first was reported in April 2022 and occurred in a 4-year-old boy in Henan province, who likely caught the virus from chickens or wild ducks at his home. The second occurred the next month in a 5-year-old boy in Hunan province, who'd recently gone to a market where live poultry were sold, although he didn't directly handle the animals. The first boy's illness became severe and he required intensive care, but the second boy's case was mild. Both children recovered.
The newly-reported third case was detected in a 56-year-old woman from Guangdong province, whose symptoms first emerged on Feb. 22, 2023. She was hospitalized for severe pneumonia on March 3 and died on March 16.
The patient had "multiple underlying conditions," according to the WHO, and had been exposed to live poultry prior to falling ill, as well as wild birds near her home. Researchers later collected samples from the patient's home and a nearby market, and they found that samples from the market tested positive for influenza A(H3), the broad category of flu viruses to which the H3N8 subtype belongs.
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No evidence of human-to-human spread of H3N8 has been detected to date.
"The available epidemiological and virological information suggests that avian influenza A(H3N8) viruses do not have the capacity for sustained transmission among humans," the WHO stated. "Therefore, the current assessment is that the likelihood of human-to-human spread is low." However, since viruses constantly evolve, it's important to continue monitoring H3N8 to detect changes that might make it more dangerous to human health.
H3N8 viruses were first detected in wild birds in the 1960s and have since been sporadically detected in live poultry in China, as well as in other animal species, including harbor seals, according to the U.S. Centers for Disease Control and Prevention (CDC). No human cases of H3N8 bird flu have ever been detected in the U.S.
