Children who have gender dysphoria will be tested for autism, according to leaked plans.
Health officials will screen these children for neurodevelopmental conditions including autism and ADHD, reports suggest.
New guidance is to be issued in the wake of the Cass Review into gender identity services in the NHS, which found the quality of studies claiming to show beneficial effects of puberty blockers for children and young people with gender dysphoria was "poor".
Puberty blockers are not prescribed on the NHS to children for the treatment of gender dysphoria, with a ban last year being made permanent in December with the agreement of devolved governments across the UK.
The new guidance - which is expected to be released imminently - is expected to see the health service move away from a "medical model" in favour of a "holistic" approach to care.
Medics will examine various aspects of children's lives when they are referred to services.
These include mental health assessments, family relationships, sexual development, the presence of learning disabilities or neurodevelopmental conditions as well as their social, cognitive and physical growth, reports in the Telegraph suggest.
"Given the high prevalence of neurodiversity identified within this population, all those attending the NHS children and young people's gender service should receive screening for neurodevelopmental conditions," the leaked documents says.
If screening "identifies the presence of neurodevelopmental conditions, including autism spectrum disorder (ASD), a referral should be considered to the paediatric neurodevelopmental service or paediatric ASD service," it adds.
An NHS England spokesperson said: "As part of NHS England's commitment to implement advice from the Cass Review, we have recently gone out to stakeholder testing on a proposed revised specification planned to replace the interim service specification for the children and young people's gender service.
"We will soon be going to full public consultation on this draft specification which sets out the new holistic assessment framework that was described by Dr Cass in her report.
"NHS England has recently changed the referral pathway so child patients can only access gender services that we commission if they're referred by a paediatrician or a child and adolescent mental health worker."
Asked if he agrees with these reported plans, health minister Stephen Kinnock told BBC Radio 4's Today Programme it was "not something I'm familiar with".
"I think the Cass review set out very clearly that change is required, that some mistakes have been made and we need to rectify those," Mr Kinnock said.
"The best way to do that now is to really look at how we get our gender services working for our young people in a way that reflects the complexity of each individual.
"So rather than taking a blanket position, it's much more about really understanding the specific circumstances, because each case is very different, and then taking the action that's required.
"And, of course, young people who are presenting with gender dysphoria need to be listened to, need to be treated with respect and dignity, but we've also got to ensure that the system isn't leading to unintended consequences."
