Chelsea are able to welcome both Raheem Sterling and Cole Palmer back from suspension for the trip to Luton, but the England international is on the bench.
The duo missed the midweek 2-1 win at home to Crystal Palace. Noni Madueke makes his first Premier League start since October in the reverse fixture, keeping Sterling out of the team after scoring a penalty to win the Crystal Palace match from the bench.
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Mykhailo Mudryk started in Sterling's place but came off with an ankle injury on Wednesday night. The winger makes the bench.
They join a lengthy injury list, including Enzo Fernandez, Reece James, Ben Chilwell, Marc Cucurella, Robert Sanchez, Wesley Fofana, Carney Chukwuemeka, Trevoh Chalobah and Lesley Ugochukwu.
Chilwell, Chalobah and Chukwuemeka are believed to be the closest to their returns but are unlikely to be ready for the weekend clash.
Chelsea look to be lining up in a 4-4-2 formation with both Armando Broja and Nicolas Jackson starting away at Kenilworth Road.
They have paired each other before and this is Jackson's last match before the Africa Cup of Nations. Christopher Nkunku drops to the bench to manage his minutes after a knee injury.
Benoit Badiashile is left out of the squad, Enzo Fernandez and Mykhailo Mudryk, who were doubts, make the bench.
Confirmed team news
Luton XI: Kaminski, Mengi, Osho, Bell, Kabore, Sambi Lokonga, Barkley, Doughty, Townsend, Brown, Adebayo
Subs: Andersen, Ogbene, Morris, Woodrow, Chong, Mpanzu, Clark, Krul, Giles
Chelsea XI: Petrovic, Gusto, Disasi, Thiago Silva, Colwill, Gallagher, Caicedo, Palmer, Jackson, Madueke, Broja
Subs: Sterling, Fernandez, Mudryk, Bettinelli, Nkunku, Maatsen, Gilchrist, Bergstrom, Matos
Time and date: 12.30pm GMT on Saturday December 30, 2023
Venue: Stamford Bridge
TV channel: TNT Sports