The Chargers had their final practice on Thursday ahead of the Week 16 game against the Bills.
Wide receiver Keenan Allen (heel) and edge defender Joey Bosa (foot) have been ruled out.
This is the second consecutive week that Allen will miss due to the injury.
Los Angeles opened Bosa’s 21-day activation window.
Cornerback Deane Leonard (heel) and linebacker Tanner Muse (knee) are doubtful.
CB Essang Bassey (concussion), tight end Nick Vannett (back) and defensive tackle Nick Williams (shoulder) are questionable.
As for the Bills, safety Micah Hyde (neck stinger) and WR Justin Shorter (hamstring) are out. CB Kair Elam (ankle), defensive end A.J. Epenesa (rib), running back Ty Johnson (shoulder) and DT DaQuan Johnson (pec) are questionable.
