Tottenham will host Manchester United in the Carabao Cup quarter-finals as Arsenal welcome Crystal Palace in a London derby.
For the first time in 14 years, it is an all-Premier League lineup for the quarter-finals, despite Chelsea and Manchester City being knocked out in the fourth round.
Spurs who have not won a trophy since lifting the League Cup in 2008, will need to make it back-to-back wins over Manchester clubs after dispatching City, having been drawn at home to United.
Ange Postecoglou’s side have already beaten the Red Devils this season - and convincingly so - but United will surely be a different prospect with a new manager incoming.
Arsenal, meanwhile, will welcome Palace to the Emirates Stadium as Mikel Arteta looks to add a first piece of silverware in almost five years.
Holders Liverpool will return to the south coast after beating Brighton 3-2 on Wednesday.
The 10-time winners will visit Southampton, while Newcastle's reward for overcoming Chelsea was a home tie against Brentford.
The Carabao Cup quarter-final ties will be played the week commencing December 16.
Carabao Cup quarter-final draw in full
Tottenham vs Manchester United
Arsenal vs Crystal Palace
Newcastle vs Brentford
Southampton vs Liverpool
