Gun Fremantle recruit Shai Bolton has been named for the crunch clash against Sydney, while Collingwood welcomed back Jordan De Goey and Mason Cox but have lost Brody Mihocek.
In other notable selection news for round two, St Kilda coach Ross Lyon dropped Zaine Cordy among four axings, former Sun Sam Day will play his first match for Brisbane, and Port dropped Jeremy Finlayson.
Bolton missed last week's 78-point loss to Geelong with a leg injury, but trained strongly on Thursday and has been named in the starting team for Sunday's game in Perth.
Sydney lost Lewis Melican (adductor) and Justin McInerney (suspended), with Hayden McLean and Peter Ladhams possible inclusions after being named on the extended bench.
De Goey and Cox are back for the Magpies against the Bulldogs on Friday night, but Mihocek will miss with what the club describes as "general soreness".
The Bulldogs have called up Oskar Baker and Buku Khamis to replace James O'Donnell (jaw) and Luke Cleary (concussion).
Young Richmond forward Liam Fawcett will become the club's fourth debutant this year after being named to take on Port Adelaide on Saturday.
Fawcett, who will follow in the footsteps of last week's debutant trio Sam Lalor, Luke Trainor and Harry Armstrong, replaces suspended forward Tom Lynch.
Port Adelaide coach Ken Hinkley is showing huge faith in the team that copped a 91-point loss to Collingwood, the only change being debutant Christian Moraes replacing Finlayson.
St Kilda named debutant Isaac Keeler for Saturday night's encounter with Geelong, while Mitch Owens returns from injury.
Cordy, Arie Schoenmaker, Harry Boyd and Angus Hastie were all dropped in the wake of last week's 63-point loss to Adelaide.
The Cats go in unchanged.
West Coast have been bolstered by the return of Liam Ryan (hamstring) for Sunday's trip to the Gabba to take on Brisbane, and Bo Allan is a chance to make his AFL debut, but Jake Waterman (back/calf) has been ruled out.
Star Brisbane forward Charlie Cameron will be given another week to recover from a calf injury, while Kai Lohmann (ankle), Brandon Starcevich (concussion) and Darcy Fort (omitted) come out of the side.
The premiers have named former Gold Coast forward Day for his Lions debut.
North Melbourne are without the suspended Jackson Archer and Griffin Logue (hamstring), but Charlie Comben (foot) is expected to retain his spot in the side against Melbourne for what will be Jack Darling's 300-game milestone.
The Demons have lost Aidan Johnson (suspension) and Caleb Windsor (foot infection), with star defender Steven May still missing with a fractured larynx.
Melbourne have named Charlie Spargo on an extended interchange bench in what could be his first AFL match since opening round last season.
Essendon have named SSP selection Tom Edwards for his AFL debut, but Kyle Langford (hamstring) and Jordan Ridley (concussion) will miss Saturday's meeting with the unchanged Crows at the MCG.
