The Issa brothers are reportedly eyeing up Boots as their latest huge acquisition.
The billionaire siblings, who got their start after buying a petrol station in Bury, are said to be looking into a multi-billion pound takeover of the chemists.
Boots owns more than 2,000 stores but its American parent company Wallgreens has put the well-known brand up for sale.
It could be bought by Asda - which was recently taken over by the Issa brothers - reports in The Telegraph suggest.
Boots is set to be auctioned in the coming weeks, with other grocery giants also expected to be interested.
Mohsin and Zuber Issa have made waves in the last few years after snapping up a number of well-know companies.
The Blackburn-based pair took on Asda in a massive deal worth around £6.8bn, which made them the first British owners of the supermarket in a decade.
They also took on fast food firm Leon and are set to open drive-thru stores around the country at locations run by their petrol station firm EG Group.
And, last week it was revealed that the Issas had planned to buy Caffe Nero.
However, that deal was called off after the coffee chain completed a £330m refinancing deal.
