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Scotland Under-21 head coach Scot Gemmill has named 16-year-olds Ben Doak and Rory Wilson in his new-look squad.
The pair make the step up from the under-17s for a friendly double-header against Northern Ireland while a number of players move up from the under-19s.
Both players made moves from Glasgow to the Premier League over the summer, Doak leaving Celtic for Liverpool and Wilson joining Aston Villa from Rangers.
Only five players remain from the squad that ended the previous European qualifying campaign with a draw in Denmark in June while Josh Doig returns from injury after a positive start to life in Serie A with Hellas Verona.
Gemmill’s squad will travel to Belfast for a match on September 22 at Danny Blanchflower Stadium before hosting their opponents at the SMISA Stadium in Paisley three days later.