Arsenal will be without Thomas Partey against Brighton after the midfielder sustained a thigh injury in the 3-0 defeat to Crystal Palace on Monday.
With Partey missing, Albert Sambi Lokonga gets a first start since January.
Kieran Tierney is out for the rest of the seasona and, perhaps surprisignly, Granit Xhaka slots in at left-back over Nuno Tavares.
“Now he needs to react on that situation, because it is a great opportunity to learn a lot in that period in your career,” said Mikel Arteta this week.
Takehiro Tomiyasu is still absent as well with a calf issue and, as a result, Cedric Soares has kept his place at right-back.
Gabriel Martinelli is handed another start on the left wing after impressing off the bench during Monday’s defeat at Palace.
Predicted Arsenal XI (4-2-3-1): Ramsdale; Cedric, White, Gabriel, Xhaka; Lokonga, Smith-Rowe; Saka, Odegaard, Martinelli; Lacazette
When: Saturday 3pm BST
Venue: Emirates Stadium
Referee: David Coote
Arsenal squad from: Leno, Ramsdale, Okonkwo; Cedric, Gabriel, Holding, Tavares, White; Elneny, Lokonga, Odegaard, Patino, Saka, Smith Rowe, Xhaka; Lacazette, Martinelli, Nketiah, Pepe.
Injured: Partey (thigh), Tierney (knee), Tomiyasu (calf).
