Antonio Conte has confirmed that he will still have the four players who were unavailable against Leeds out of the matchday squad when Tottenham travel to Middlesbrough.
Spurs make the trip to Teesside to play their FA Cup tie on the back of a 4-0 victory over Leeds on Saturday, which was a positive response from their midweek defeat against Burnley.
The Lilywhites will play the cup competition match after beating Morecambe and then Brighton to get to the fifth round.
Chris Wilder's side beat Manchester United on penalties in the fourth round to get to this stage of the competition and therefore it won't be an easy game for Conte's side against the Championship outfit who are pushing for promotion to the Premier League.
Ahead of Tuesday's match, the Italian provided the disappointing injury news in his pre-match press conference.
"Same squad as we have to face Leeds. No [Oliver] Skipp, [Japhet] Tanganga, [Lucas] Moura or [Rodrigo] Bentancur," he admitted.
Skipp is out with a groin injury, Tanganga has an issue with his knee and Bentancur injured his ankle in the defeat against Burnley.
The trio were already confirmed to be out of the matchday squad against Leeds when Conte spoke to the media on Friday but Moura was only ruled out of the squad on the day of the game, after it was revealed he had sustained an injury in training on Friday.
All four players provide the Italian with some much needed options in matches and both Skipp and Tanganga have been unavailable since Tottenham's 2-0 defeat to Chelsea in the Premier League.
Bentancur's injury is a blow to Spurs not long after he arrived in the capital during the summer and although Dejan Kulusevski has been playing well alongside Son Heung-min and Harry Kane, Moura also provides another attacking outlet.
This leaves Conte with a lack of options outside his strongest XI and has left room on the bench for the likes of Dane Scarlett, Harvey White and Alfie Devine.
The 52-year-old will need to make some decisions in regards to how he lines up against Middlesbrough on Tuesday, to give his side the best possible chance of progressing in the cup competition and get one step closer to ending Tottenham's near-14 year trophy drought.
