Alex Iwobi has been handed his first Everton start since December and Donny van de Beek earns a full debut against Leeds United on Saturday afternoon.
Dominic Calvert-Lewin and Jonjoe Kenny also come into the starting line-up as Frank Lampard makes four changes from his side that took on Newcastle United in midweek.
FOLLOW LIVE: Everton vs Leeds United score updates and analysis
Demarai Gray, Yerry Mina, Andre Gomes and Andros Townsend are the players who drop out of the side after Tuesday's defeat.
Calvert-Lewin was named on the bench for the midweek visit to Newcastle as he continues to work his way back to full fitness, with the striker scoring in the reverse fixture against Leeds earlier in the season.
Iwobi's last start for the Blues was in the battling 1-1 draw with Chelsea at Stamford Bridge, while Kenny was last in the line-up for the visit of Aston Villa to Goodison Park last month.
Everton XI: Pickford, Coleman, Holgate, Keane, Kenny, Allan, Van de Beek, Iwobi, Gordon, Richarlison, Calvert-Lewin
Subs: Begovic, Patterson, Townsend, Tosun, Gomes, Branthwaite, Rondon, El Ghazi, Dele
