A devastating maiden T20I hundred from Rovman Powell helped the West Indies go 2-1 up in the series as his side completed a 20-run win over England.
Powell smashed a total of ten sixes on his recall to the side and enjoyed an excellent partnership with Nicholas Pooran, while Tom Banton and Phil Salt's half-centuries came in vain.
England made five changes to their line-up, with three debutants coming into the side and Moeen Ali named as captain after Eoin Morgan suffered a quad injury during the warm-up.
Salt, George Garton and Harry Brook were all handed debuts, Tymal Mills was recalled and Liam Livingstone returned to the side after being sidelined by a non-Covid related illness.
Stand-in skipper Moeen won the toss and opted to bowl first and Garton was immediately into the action, taking the new ball alongside Reece Topley and picking up a wicket in his first over.
The left-arm quick bowled Brandon King with a beauty, sending the opener packing for just ten.
Shai Hope also fell cheaply, with Livingstone getting him caught behind for four, before Nicholas Pooran and Rovman Powell shared a devastating partnership.
The pair put on 122 runs, with Pooran smashing 70 off just 43 balls and Powell blasting 107 off 53 balls.
Powell in particular was outstanding as he struck 10 sixes, including one that went a mammoth 108 metres.
Pooran was caught at long on off Adil Rashid, while Powell was caught at long-off off Topley.
Fabian Allen fell to Tymal Mills for a golden duck, but Romario Shepherd and Kieron Pollard finished the innings well for the hosts as they reached 224-5.
In response, England needed to get off to an absolute flier and, after taking 11 balls to get their eye in, Tom Banton and Jason Roy blasted their first sixes off Jason Holder and Sheldon Cottrell respectively.
However, Roy soon departed for 19, holing out in the deep off Shepherd after a miscue.
England continued to attack, though, with Banton and James Vince adding 46 runs off just 27 balls before Vince hit a long-hop from Akeal Hosein straight to the fielder.
Moeen was then out in ugly fashion for a duck as he was deceived by a slower ball from Kieron Pollard and spooned a catch to backward point.
Banton continued to motor and brought up his half-century off just 29 balls, but he struggled to find someone to stay with him as Livingstone holed out for just 11 off Shepherd.
After reaching 73, his highest international score in any format, Banton fell to Pollard in a major blow to England's chase.
Salt did his utmost to continue to where Banton left off, smashing 57 off 24 balls, but the 25-year-old was fighting a losing battle as England fell 21 runs short of their target.
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Topley takes his opportunity
The only seamer to keep his place in the side, Topley once again impressed with figures of 1-30.
The left-armer was one of only two England bowlers with an economy rate below 10 and has undoubtedly been the standout seamer in the absence of regulars Mark Wood and Chris Woakes.
In the second T20I, he picked up 1-18 and conceded just eight runs in the 19th over while Jordan and Mahmood went for 23 and 28 either side of him.
Having not played a T20I since 2016 before this series, Topley is certainly making the most of his opportunity and will have his sights firmly set on featuring in this year's T20 World Cup.
Powell blasts a ton
While England made wholesale changes to their line-up, the West Indies made just one, replacing Odean Smith with Powell.
Powell has failed to nail down a spot in the West Indies side since making his debut in 2016, but he was in inspired form on Wednesday and smashed his first T20I hundred.
The 28-year-old finished with 107 off just 53 and shared a destructive 122-run partnership with the always dangerous Pooran to get the West Indies up to an imposing total of 224.
"It's a very proud moment," Powell told BT Sport. "For the last five or six months I've been working hard and when you work hard it's good to see payoff."
England's death bowling struggles
England's bowling at the death has long been an issue, with Morgan's side having the highest economy rate in the last five overs of any full member side, and that issue has persisted in the Caribbean.
In the second T20I, Jordan and Mahmood were climbed into by Shepherd and Hosein as England clung on to win the game by just one run.
Jordan and Mahmood made way for Garton and Mills in the third T20I, but the two Sussex stars also
After going for runs at the death in the second T20I, Chris Jordan and Saqib Mahmood were replaced by Garton and Mills.
Mills conceded a combined 30 runs from his two overs at the death, while Garton went 19 when he bowled the 18th.
Banton at his best
After getting out just as he had started to get going in the previous game, Banton played brilliantly in this match.
His innings of 73 was his highest in an England shirt and almost single-handedly kept his side in with a chance of completing a remarkable victory.
Banton is a hugely talented young player who has drawn comparisons to Kevin Pietersen, but England opportunities have been limited due to the regular presence of Roy, Jos Buttler and Jonny Bairstow at the top.
However, his 73 was a timely reminder of his ability and all the more impressive given Salt was the only other England batter to pass 20.
Salt impresses out of position
Asked to bat at number six for the first time ever in a T20 career which has spanned more than 100 games, Salt did his utmost to try and power England to victory.
An opener by trade, Salt impressed on his T20I debut as he struck 57 off just 24 balls.
Having spent six years living in Barbados as a child it was something of a homecoming for Salt and, although England came up short, he certainly made the most of his opportunity.
With Banton impressing in this game as well and the likes of Buttler and Bairstow to return, it is unlikely Salt will get many opportunities to open for England so the role of a middle-order finisher could be the only way he can nail down a spot in the side.
As far as auditions go, this was a pretty good one.
