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USA Today Sports Media Group
USA Today Sports Media Group
Sport
Kyle Madson

49ers open Week 16 practice with 3 players missing, 5 limited

With the postseason virtually out of reach, the San Francisco 49ers can start turning an eye toward the 2025 season. However, it doesn’t appear the 49ers are aiming to start shutting things down with three games to go.

San Francisco’s practice participation report from Wednesday featured a trio of players missing, including left tackle Trent Williams and running back Isaac Guerendo. Williams is still working through an ankle issue. Guerendo had a hamstring injury crop up during the team’s Week 15 loss to the Los Angeles Rams.

Beyond that, players like defensive end Nick Bosa and linebacker Dre Greenlaw were still participating in practice on a limited basis despite playing through injury issues of their own.

Bosa has been dealing with hip and oblique problems since Week 10, and they cost him three games before his return against the Rams. Greenlaw made his season debut in Week 15 after recovering from a torn Achilles. He left the game with what head coach Kyle Shanahan classified as fatigue and soreness. That both players were in practice to begin the week is a good sign for their chances to suit up Sunday in Miami.

Did not participate

DT Maliek Collins (illness)
RB Isaac Guerendo (hamstring)
LT Trent Williams (ankle)

Limited participation

DE Nick Bosa (hip, oblique)
LB Dre Greenlaw (Achilles, knee)
OT Jaylon Moore (hip)
S Malik Mustapha (chest)
G Nick Zakelj (illness)

Full participation

G Aaron Banks (elbow)
S Ji’Ayir Brown (groin)
LB Demetrius Flannigan-Fowles (knee)
S Talanoa Hufanga (wrist)
LB Dee Winters (neck)

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